Abstract CRISPR-Cas9 genome editing has promising therapeutic potential for genetic diseases and cancers. but safety could be a concern. Here we use whole genomic analysis by 10x linked-read sequencing and optical genome mapping to interrogate the genome integrity after editing and in comparison to four parental cell lines. In addition to the previously reported large structural varia... https://fitnessgravesyardes.shop/product-category/pin-and-rack-service-kit/
Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing
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