Herein. we propose a new deep neural network model based on invariant information clustering (IIC). proposed by Ji et al. to improve the modeling performance of the leave-one-site-out cross-validation (LOSO-CV) for a multi-source dataset. https://www.roneverhart.com/2-1-2-x-1-4-x-36-Smooth-Saddle-Threshold-NGP-410-36/