Abstract Molecular diagnostics is an increasingly important clinical tool. especially in routine sampling. We evaluated two non-invasive methods (oral swabs and mouthwashes) for sampling nucleic acids from the oral/pharyngeal area. We created a workflow from sample collection (n = 59) to RT-qPCR based analysis. https://www.roneverhart.com/Grace-Design-M801-MK2-High-Fidelity-p15168/